Shanghai Medicilon Inc
1011 Halei Rd., Suite 502
Zhangjiang Hi-Tech Park
Shanghai 201203, China
Phone: +86 21 51320228 (China)
+1 651 334 3295 (USA)
FAX: +86 21 51320222 (China)
+1 248 412 0014 (USA)
sales@medicilon.com
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CORPORATE MISSION
To provide chemistry services and pharmaceutical services to pharmaceutical
companies and biotech companies and to become a partner in drug discovery and
development.
KEY PERSONNEL
Chun-Lin Chen, Ph.D.
President and CEO
clchen@medicilon.com
Jintao Zhang, Ph.D.
Vice President
jzhang@medicilon.com
Chen C. Mao, Ph.D.
Vice President
cmao@medicilon.com
Sara H. Moran, Ph.D.
Director of Marketing and Business Development
sales@medicilon.com
info@medicilon.com
HISTORY
Shanghai Medicilon Inc, founded in 2003, is a pharmaceutical research and development
company located at Zhangjiang Hi-Tech Park, Shanghai, China. The company occupies
10,000 square feet of R&D facilities equipped with state-of- the-art instruments.
Shanghai Medicilon, Inc is operated by a team of managers with many years of
working experience in US-based pharmaceutical companies. The company's core
business is to provide chemistry services and pharmaceutical services to pharmaceutical
companies and biotech companies.
SERVICES
Shanghai Medicilon, Inc. offers drug discovery and development services ranging
from protein production, biological assays, and chemistry services to pharmacokinetic
and bioanalysis services. Programs integrate the expertise of the company's
scientists in:
- High throughput parallel synthesis of screening compounds and focused combinatorial
libraries
- Custom synthesis of combinatorial building blocks, intermediates, reference
compounds and drug candidates
- Pharmacokinetics services
- Metabolism services
- Bioanalysis services
- Pharmacology services
- Protein production and biological screening
Custom Synthesis Services
- From milligram to kilograms scale
- Reagents
- Pharmaceutical intermediates
- Building blocks and scaffolds
- Reference standards
- Impurities
- Synthesis of radio-labeled compounds
High-Speed Parallel Synthesis/Combinatorial Chemistry Services
- Custom focused libraries to support clients’ hit-to-lead programs
- Target-directed libraries for lead identification optimization
- Custom library design and synthesis of drug-like compounds/screening samples
- Library design and analysis
Pharmacokinetic Services
- Animals (mice, rats, rabbits, dogs and monkeys)
- Preclinical pharmacokinetics characterization and toxicokinetics
- Formulation evaluations and bioavailability
- Crossover studies
- Mass balance
- Tissue distribution
- In vivo metabolism
- Protein binding and blood cell partitioning
- Cassette (N in 1) dosing and analysis
- Effect of gender on pharmacokinetics
- Effect of food on pharmacokinetics
- Drug interaction studies
- Biliary excretion
Bioanalytical Services
- HPLC and LC/MSMS
- Method feasibility assessments
- Method development
- Method validation
- Analysis of drug and metabolite(s) in biological fluids
- Metabolite profiling and mass balance assessment
Metabolism Services
- Microsomes, S9 fractions and cytosol (mouse, rat, dog, monkey and human)
- Determine the metabolite profile of drug candidates
- Identify Phase I or Phase II enzymes responsible for metabolite formation
- Identify pharmacogenetic effects on human drug metabolism
- Predict drug interactions due to inhibition or induction of drug metabolizing
enzymes
- In vitro metabolic stability (microsomes, S9 and cytosol)
- Drug-drug interaction studies
- In vivo P450 induction and inhibition
- P450 isoforms IC50 determination and Ki/Km determination
- Identification of metabolite(s)
- Evaluation of species difference in drug metabolism
- Determination of Km and Vmax values for metabolite formation
Pharmacology/Toxicology Services
- Normal animal and diseased animal models
- Type II diabetes rat model
- Spontaneously hypertensive rat model (SHR/N)
- Spontaneously hypertensive rats-stroke prone (SHR/SP)
- Severe combined immune deficiency (SCID) mice
- Cancer models
Biological Services
- Target protein production
- Biological assays
